Protein Details: P2X purinoceptor 1

Protein ID

ICDB_Pro_0583

Protein Name

P2X purinoceptor 1

Gene Name

P2RX1; P2X1

Organism

Homo sapiens (Human)

Length

399 amino acids

AlphaFoldDB

AF-P51575-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium;sodium and with relatively high calcium permeability. Furthermore;CTP functions as a weak affinity agonist for P2RX1. Plays a role a role in urogenital;immune and cardiovascular function (By similarity). Specifically;plays an important role in neurogenic contraction of smooth muscle of the vas deferens;and therefore is essential for normal male reproductive function (By similarity). In addition;contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets;contributes to platelet activation and aggregation and thereby;also to thrombosis (By similarity). On neutrophils;it is involved in chemotaxis and in mitigating the activation of circulating cells.

Sequence

MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 68; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 68; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 70; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 70; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 140; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 186; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 186; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 286; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 290; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 290; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 292; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 292; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 309; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 309; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"

Disease

Bleeding Disorder;Platelet-Type;8 and Bernard-Soulier Syndrome

Location

Expressed on neutrophils and platelets (PubMed:19635923). Expressed on urinary bladder smooth muscle (PubMed:8834001).

DOI ID

10.1016/0167-4781(96)00112-1; 10.1074/jbc.273.19.11544; 10.1038/nature04689; 10.1101/gr.2596504; 10.1113/jphysiol.1996.sp021777; 10.1016/s0014-2999(99)00350-7; 10.1124/mol.61.2.303; 10.1074/jbc.m308964200; 10.1523/jneurosci.5429-03.2004; 10.4049/jimmunol.0804007; 10.1074/jbc.m110.148940; 10.1111/jnc.12012; 10.1074/jbc.c000305200

RefSeq

NP_002549.1